Ontology highlight
ABSTRACT:
SUBMITTER: Deng T
PROVIDER: S-EPMC3619392 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Deng Tuo T Lyon Christopher J CJ Minze Laurie J LJ Lin Jianxin J Zou Jia J Liu Joey Z JZ Ren Yuelan Y Yin Zheng Z Hamilton Dale J DJ Reardon Patrick R PR Sherman Vadim V Wang Helen Y HY Phillips Kevin J KJ Webb Paul P Wong Stephen T C ST Wang Rong-Fu RF Hsueh Willa A WA
Cell metabolism 20130301 3
Adipose-resident T cells (ARTs) regulate metabolic and inflammatory responses in obesity, but ART activation signals are poorly understood. Here, we describe class II major histocompatibility complex (MHCII) as an important component of high-fat-diet (HFD)-induced obesity. Microarray analysis of primary adipocytes revealed that multiple genes involved in MHCII antigen processing and presentation increased in obese women. In mice, adipocyte MHCII increased within 2 weeks on HFD, paralleling incre ...[more]