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Nicotine withdrawal modulates frontal brain function during an affective Stroop task.


ABSTRACT: Among nicotine-dependent smokers, smoking abstinence disrupts multiple cognitive and affective processes including conflict resolution and emotional information processing (EIP). However, the neurobiological basis of abstinence effects on resolving emotional interference on cognition remains largely uncharacterized. In this study, functional magnetic resonance imaging (fMRI) was used to investigate smoking abstinence effects on emotion-cognition interactions.Smokers (n?=?17) underwent fMRI while performing an affective Stroop task (aST) over two sessions: once following 24-h abstinence and once following smoking as usual. The aST includes trials that serially present incongruent or congruent numerical grids bracketed by neutral or negative emotional distractors and view-only emotional image trials. Statistical analyses were conducted using a statistical threshold of p?

SUBMITTER: Froeliger B 

PROVIDER: S-EPMC3619410 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Nicotine withdrawal modulates frontal brain function during an affective Stroop task.

Froeliger Brett B   Modlin Leslie L   Wang Lihong L   Kozink Rachel V RV   McClernon F Joseph FJ  

Psychopharmacology 20111012 4


<h4>Background</h4>Among nicotine-dependent smokers, smoking abstinence disrupts multiple cognitive and affective processes including conflict resolution and emotional information processing (EIP). However, the neurobiological basis of abstinence effects on resolving emotional interference on cognition remains largely uncharacterized. In this study, functional magnetic resonance imaging (fMRI) was used to investigate smoking abstinence effects on emotion-cognition interactions.<h4>Methods</h4>Sm  ...[more]

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