Dataset Information

Update on the Epidemiology of Melanoma.

ABSTRACT: Cutaneous malignant melanoma (CMM) has been increasing steadily in incidence over the past 30 years. Recent studies have explored associations between CMM and varying physiologic risk factors, such as nevi or hair and eye color, in addition to historical features such as a personal history of nonmelanoma skin cancer (NMSC), childhood cancers, Parkinson's Disease, hormone exposure and family history of CMM. Genome-wide association studies have also uncovered many genetic determinants of CMM risk. Ultimately, ultraviolet (UV) radiation exposure remains the most important modifiable risk factor for CMM. Organ transplant recipients, and nonsteroidal anti-inflammatory usage may also play a role. While risk factors are important to identify, effective campaigns to reduce the burden of disease through early detection and prevention are essential. We present detailed data regarding these facets of care for the CMM patient, and provide an update on the epidemiology of CMM.

SUBMITTER: Chen ST

PROVIDER: S-EPMC3619431 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Update on the Epidemiology of Melanoma.

Chen Steven T ST Geller Alan C AC Tsao Hensin H

Current dermatology reports 20130301 1

Cutaneous malignant melanoma (CMM) has been increasing steadily in incidence over the past 30 years. Recent studies have explored associations between CMM and varying physiologic risk factors, such as nevi or hair and eye color, in addition to historical features such as a personal history of nonmelanoma skin cancer (NMSC), childhood cancers, Parkinson's Disease, hormone exposure and family history of CMM. Genome-wide association studies have also uncovered many genetic determinants of CMM risk. ...[more]

PMID: 23580930

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Project description:BackgroundCanine babesiosis is an emerging or re-emerging disease caused by Babesia and Theileria protozoans, also called piroplasms, transmitted by Ixodid ticks. In Europe, four etiological agents have been identified to date, namely Babesia canis, B. vogeli, B. gibsoni and Theileria annae. France has a high prevalence of canine babesiosis and two tick species, Dermacentor reticulatus and Rhipicephalus sanguineus, are supposed to transmit B. canis and B. vogeli respectively. In southern France, where dog infections with B. vogeli were recently confirmed, no comprehensive study was performed to date on piroplasm species infecting dogs. Thus, a large scale survey involving veterinary clinics, kennels and tick collection from the environment was conducted from 2010 to 2012 in this area.ResultsFrom 2010 to 2012, 140 dog blood samples and 667 ticks were collected. All blood and a subset of ticks were screened for the presence of piroplasms by PCR amplification of 18S rDNA. B. vogeli, B. canis and T. annae were detected in 13.6, 12.9 and 0.7 % dogs respectively. B. vogeli and B. canis were detected in 10.5 % and in 1.6 % R. sanguineus ticks including 1.3 % co-infections. B. canis was the only species detected in D. reticulatus ticks (9.7 %). B. canis infections were only recorded in the southwest of France whereas B. vogeli was mainly found in the southeast. Finally, a significantly higher prevalence of B. vogeli infection was found in Gard compared to Corsica and Drôme regions, both in dogs (p < 0.002) and R. sanguineus ticks (p < 0.02) although R. sanguineus was the main ticks species removed from dogs in those three areas.ConclusionsThe survey confirmed the circulation of both B. canis and B. vogeli in dogs in southern France with differences in distribution probably linked to the distribution of their respective vectors. It also showed differences in prevalence of B. vogeli infection in areas similar in terms of risk of dogs infestation with R. sanguineus. Further studies focusing on genetic and microbiota of R. sanguineus ticks should be conducted to explore other biological interactions that may explain the differences observed.

Dataset Information

Update on the Epidemiology of Melanoma.

Publications

Update on the Epidemiology of Melanoma.

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