Ontology highlight
ABSTRACT:
SUBMITTER: Coquet JM
PROVIDER: S-EPMC3620350 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Coquet Jonathan M JM Ribot Julie C JC Bąbała Nikolina N Middendorp Sabine S van der Horst Gerda G Xiao Yanling Y Neves Joana F JF Fonseca-Pereira Diogo D Jacobs Heinz H Pennington Daniel J DJ Silva-Santos Bruno B Borst Jannie J
The Journal of experimental medicine 20130401 4
CD4(+)Foxp3(+) regulatory T cells (Treg cells) are largely autoreactive yet escape clonal deletion in the thymus. We demonstrate here that CD27-CD70 co-stimulation in the thymus rescues developing Treg cells from apoptosis and thereby promotes Treg cell generation. Genetic ablation of CD27 or its ligand CD70 reduced Treg cell numbers in the thymus and peripheral lymphoid organs, whereas it did not alter conventional CD4(+)Foxp3(-) T cell numbers. The CD27-CD70 pathway was not required for pre-Tr ...[more]