Ontology highlight
ABSTRACT:
SUBMITTER: Zolak JS
PROVIDER: S-EPMC3620419 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Zolak Jason S JS Jagirdar Rajesh R Surolia Ranu R Karki Suman S Oliva Octavio O Hock Thomas T Guroji Purushotham P Ding Qiang Q Liu Riu-Ming RM Bolisetty Subhashini S Agarwal Anupam A Thannickal Victor J VJ Antony Veena B VB
The American journal of pathology 20130209 4
The origin of the myofibroblast in fibrotic lung disease is uncertain, and no effective medical therapy for fibrosis exists. We have previously demonstrated that transforming growth factor-β1 (TGF-β1) induces pleural mesothelial cell (PMC) transformation into myofibroblasts and haptotactic migration in vitro. Whether PMC differentiation and migration occurs in vivo, and whether this response can be modulated for therapeutic benefit, is unknown. Here, using mice recombinant for green fluorescent ...[more]