Prenatal and postnatal bisphenol A exposure and body mass index in childhood in the CHAMACOS cohort.

ABSTRACT:

Background

Bisphenol A (BPA), a widely used endocrine-disrupting chemical, has been associated with increased body weight and fat deposition in rodents.

Objectives

We examined whether prenatal and postnatal urinary BPA concentrations were associated with body mass index (BMI), waist circumference, percent body fat, and obesity in 9-year-old children (n = 311) in the CHAMACOS longitudinal cohort study.

Methods

BPA was measured in spot urine samples collected from mothers twice during pregnancy and from children at 5 and 9 years of age.

Results

Prenatal urinary BPA concentrations were associated with decreased BMI at 9 years of age in girls but not boys. Among girls, being in the highest tertile of prenatal BPA concentrations was associated with decreased BMI z-s

SUBMITTER: Harley KG 

PROVIDER: S-EPMC3620748 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature