Dataset Information

Early-life exposure to outdoor air pollution and respiratory health, ear infections, and eczema in infants from the INMA study.

ABSTRACT:

Background

Prenatal and early-life periods may be critical windows for harmful effects of air pollution on infant health.

Objectives

We studied the association of air pollution exposure during pregnancy and the first year of life with respiratory illnesses, ear infections, and eczema during the first 12-18 months of age in a Spanish birth cohort of 2,199 infants.

Methods

We obtained parentally reported information on doctor-diagnosed lower respiratory tract infections (LRTI) and parental reports of wheezing, eczema, and ear infections. We estimated individual exposures to nitrogen dioxide (NO(2)) and benzene with temporally adjusted land use regression models. We used log-binomial regression models and a combined random-effects meta-analysis to estimate the effects of air pollution exposure on health outcomes across the four study locations.

Results

A 10-µg/m(3) increase in average NO(2) during pregnancy was associated with LRTI [relative risk (RR) = 1.05; 95% CI: 0.98, 1.12] and ear infections (RR = 1.18; 95% CI: 0.98, 1.41). The RRs for an interquartile range (IQR) increase in NO(2) were 1.08 (95% CI: 0.97, 1.21) for LRTI and 1.31 (95% CI: 0.97, 1.76) for ear infections. Compared with NO(2), the association for an IQR increase in average benzene exposure was similar for LRTI (RR = 1.06; 95% CI: 0.94, 1.19) and slightly lower for ear infections (RR = 1.17; 95% CI: 0.93, 1.46). Associations were slightly stronger among infants whose mothers spent more time at home during pregnancy. Air pollution exposure during the first year was highly correlated with prenatal exposure, so we were unable to discern the relative importance of each exposure period.

Conclusions

Our findings support the hypothesis that early-life exposure to ambient air pollution may increase the risk of upper and lower respiratory tract infections in infants.

SUBMITTER: Aguilera I

PROVIDER: S-EPMC3621204 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Early-life exposure to outdoor air pollution and respiratory health, ear infections, and eczema in infants from the INMA study.

Aguilera Inmaculada I Pedersen Marie M Garcia-Esteban Raquel R Ballester Ferran F Basterrechea Mikel M Esplugues Ana A Fernández-Somoano Ana A Lertxundi Aitana A Tardón Adonina A Sunyer Jordi J

Environmental health perspectives 20121205 3

<h4>Background</h4>Prenatal and early-life periods may be critical windows for harmful effects of air pollution on infant health.<h4>Objectives</h4>We studied the association of air pollution exposure during pregnancy and the first year of life with respiratory illnesses, ear infections, and eczema during the first 12-18 months of age in a Spanish birth cohort of 2,199 infants.<h4>Methods</h4>We obtained parentally reported information on doctor-diagnosed lower respiratory tract infections (LRTI ...[more]

PMID: 23221880

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Dataset Information

Early-life exposure to outdoor air pollution and respiratory health, ear infections, and eczema in infants from the INMA study.

Background

Objectives

Methods

Results

Conclusions

Publications

Early-life exposure to outdoor air pollution and respiratory health, ear infections, and eczema in infants from the INMA study.

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