Ontology highlight
ABSTRACT:
SUBMITTER: Lee JC
PROVIDER: S-EPMC3621463 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Nature communications 20120626
Protein methylation plays important roles in most, if not all, cellular processes. Lysine and arginine methyltransferases are known to regulate the function of histones and non-histone proteins through the methylation of specific sites. However, the role of the carboxyl-methyltransferase protein L-isoaspartyl methyltransferase (PIMT) in the regulation of protein functions is relatively less understood. Here we show that PIMT negatively regulates the tumour suppressor protein p53 by reducing p53 ...[more]