Inhibition of Ras-Effector Interaction by Cyclic Peptides.
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ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC3621770 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
Inhibition of Ras-Effector Interaction by Cyclic Peptides.
Wu Xianghong X Upadhyaya Punit P Villalona-Calero Miguel A MA Briesewitz Roger R Pei Dehua D
MedChemComm 20130201 2
A combinatorial library of 6 × 10<sup>6</sup> cyclic peptides was synthesized in the one bead-two compound format, with each bead displaying a unique cyclic peptide on its surface and a linear peptide encoding tag in its interior. Screening of the library against K-Ras identified compounds that bound K-Ras with submicromolar affinity and disrupted its interaction with effector proteins. ...[more]
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