Ontology highlight
ABSTRACT:
SUBMITTER: Nadin BM
PROVIDER: S-EPMC3621905 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nadin Brian M BM Pfaffinger Paul J PJ
PloS one 20130409 4
Dipeptidyl Peptidase-like Protein 6 (DPP6) is widely expressed in the brain where it co-assembles with Kv4 channels and KChIP auxiliary subunits to regulate the amplitude and functional properties of the somatodendritic A-current, ISA. Here we show that in cerebellar granule (CG) cells DPP6 also regulates resting membrane potential and input resistance by increasing the amplitude of the IK(SO) resting membrane current. Pharmacological analysis shows that DPP6 acts through the control of a channe ...[more]