Ontology highlight
ABSTRACT:
SUBMITTER: Freedman KJ
PROVIDER: S-EPMC3622078 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Freedman Kevin J KJ Haq S Raza SR Edel Joshua B JB Jemth Per P Kim Min Jun MJ
Scientific reports 20130101
Single molecule methods have provided a significantly new look at the behavior of biomolecules in both equilibrium and non-equilibrium conditions. Most notable are the stretching experiments performed by atomic force microscopes and laser tweezers. Here we present an alternative single molecule method that can unfold a protein domain, observed at electric fields greater than 10(6) V/m, and is fully controllable by the application of increasing voltages across the membrane of the pore. Furthermor ...[more]