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ABSTRACT:
SUBMITTER: Kalisman N
PROVIDER: S-EPMC3622207 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Kalisman Nir N Schröder Gunnar F GF Levitt Michael M
Structure (London, England : 1993) 20130307 4
In eukaryotes, CCT is essential for the correct and efficient folding of many cytosolic proteins, most notably actin and tubulin. Structural studies of CCT have been hindered by the failure of standard crystallographic analysis to resolve its eight different subunit types at low resolutions. Here, we exhaustively assess the R value fit of all possible CCT models to available crystallographic data of the closed and open forms with resolutions of 3.8 Å and 5.5 Å, respectively. This unbiased analys ...[more]