Differential genomic variation between short- and long-term bacterial evolution revealed by ultradeep sequencing.
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ABSTRACT:
SUBMITTER: Feng Y
PROVIDER: S-EPMC3622303 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
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Differential genomic variation between short- and long-term bacterial evolution revealed by ultradeep sequencing.
Feng Ye Y Chen Hsiu-Ling HL Chiu Cheng-Hsun CH
Genome biology and evolution 20130101 3
Mutation and selection are both thought to impact significantly the nucleotide composition of bacterial genomes. Earlier studies have compared closely related strains to obtain mutation patterns based on the hypothesis that these bacterial strains had diverged so recently that selection will not have had enough time to play its role. In this study, we used a SOLiD autosequencer that was based on a dual-base encoding scheme to sequence the genome of Staphylococcus aureus with a mapping coverage o ...[more]
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