Ontology highlight
ABSTRACT:
SUBMITTER: Camacho L
PROVIDER: S-EPMC3622318 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Camacho Luz L Meca-Cortés Oscar O Abad José Luis JL García Simón S Rubio Nuria N Díaz Alba A Celià-Terrassa Toni T Cingolani Francesca F Bermudo Raquel R Fernández Pedro L PL Blanco Jerónimo J Delgado Antonio A Casas Josefina J Fabriàs Gemma G Thomson Timothy M TM
Journal of lipid research 20130219 5
Acid ceramidase (AC) catalyzes the hydrolysis of ceramide into sphingosine, in turn a substrate of sphingosine kinases that catalyze its conversion into the mitogenic sphingosine-1-phosphate. AC is expressed at high levels in several tumor types and has been proposed as a cancer therapeutic target. Using a model derived from PC-3 prostate cancer cells, the highly tumorigenic, metastatic, and chemoresistant clone PC-3/Mc expressed higher levels of the AC ASAH1 than the nonmetastatic clone PC-3/S. ...[more]