Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase.
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ABSTRACT:
SUBMITTER: Dobson EP
PROVIDER: S-EPMC3622336 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase.
Dobson Eleanor P EP Barrow Colin J CJ Kralovec Jaroslav A JA Adcock Jacqui L JL
Journal of lipid research 20130307 5
Resolvins and protectins are important anti-inflammatory and pro-resolution compounds derived from the enzymatic oxidation of omega-3 fatty acids all-cis-5,8,11,14,17-eicosapentaenoic acid (EPA) and all-cis-4,7,10,13,16,19-docosahexaenoic acid (DHA). We have developed a simple, controlled method to synthesize an array of resolvin and protectin analogs from fatty acid starting materials using soybean 15-lipoxygenase. The conditions were optimized for the production of both mono- and dihydroxy der ...[more]
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