Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.

ABSTRACT:

Rationale

A genome-wide association study (GWAS) for circulating chronic obstructive pulmonary disease (COPD) biomarkers could identify genetic determinants of biomarker levels and COPD susceptibility.

Objectives

To identify genetic variants of circulating protein biomarkers and novel genetic determinants of COPD.

Methods

GWAS was performed for two pneumoproteins, Clara cell secretory protein (CC16) and surfactant protein D (SP-D), and five systemic inflammatory markers (C-reactive protein, fibrinogen, IL-6, IL-8, and tumor necrosis factor-α) in 1,951 subjects with COPD. For genome-wide significant single nucleotide polymorphisms (SNPs) (P < 1 × 10(-8)), association with COPD susceptibility was tested in 2,939 cases with COPD and 1,380 smoking control subjects. The as

SUBMITTER: Kim DK 

PROVIDER: S-EPMC3622441 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature