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Sticky nanoparticles: a platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate.

ABSTRACT: Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a Zn(II)-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).

SUBMITTER: Liu G

PROVIDER: S-EPMC3622591 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Sticky nanoparticles: a platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate.

Liu Gang G Choi Ki Young KY Bhirde Ashwinkumar A Swierczewska Magdalena M Yin Juan J Lee Sang Wook SW Park Jae Hyung JH Hong Jong In JI Xie Jin J Niu Gang G Kiesewetter Dale O DO Lee Seulki S Chen Xiaoyuan X

Angewandte Chemie (International ed. in English) 20111123 2

Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a Zn(II)-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme). ...[more]

PMID: 22110006

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