Ontology highlight
ABSTRACT:
SUBMITTER: Pramanik R
PROVIDER: S-EPMC3622767 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Pramanik Rocky R Sheng Xia X Ichihara Brian B Heisterkamp Nora N Mittelman Steven D SD
Leukemia research 20130117 5
Obesity is associated with an increased risk of acute lymphoblastic leukemia (ALL) relapse. Using mouse and cell co-culture models, we investigated whether adipose tissue attracts ALL to a protective microenvironment. Syngeneically implanted ALL cells migrated into adipose tissue within ten days. In vitro, murine ALL cells migrated towards adipose tissue explants and 3T3-L1 adipocytes. Human and mouse ALL cells migrated toward adipocyte conditioned media, which was mediated by SDF-1α. In additio ...[more]