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Role of ventral subiculum in context-induced reinstatement of heroin seeking in rats.

ABSTRACT: In rats, reexposure to heroin-paired contexts after extinction of lever responding in a different context reinstates heroin seeking. Previous reports indicate that ventral hippocampus/Ca1 region plays a critical role in cocaine-, cue- and context-induced reinstatement of cocaine seeking. Here, we examined whether ventral subiculum, the output region of ventral hippocampus, is involved in context-induced reinstatement of heroin seeking. We found that reversible inactivation of ventral subiculum, but not posterior Ca1, with the gamma-aminobutyric acid agonists muscimol?+?baclofen decreased context-induced reinstatement of heroin seeking. Our findings, together with previous studies on cocaine seeking, indicate a critical role of ventral subiculum in context-induced relapse across drug classes.

SUBMITTER: Bossert JM

PROVIDER: S-EPMC3622847 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Role of ventral subiculum in context-induced reinstatement of heroin seeking in rats.

Bossert Jennifer M JM Stern Anna L AL

Addiction biology 20121212 3

In rats, reexposure to heroin-paired contexts after extinction of lever responding in a different context reinstates heroin seeking. Previous reports indicate that ventral hippocampus/Ca1 region plays a critical role in cocaine-, cue- and context-induced reinstatement of cocaine seeking. Here, we examined whether ventral subiculum, the output region of ventral hippocampus, is involved in context-induced reinstatement of heroin seeking. We found that reversible inactivation of ventral subiculum, ...[more]

PMID: 23231571

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