Synthesis, Characterization, Mossbauer Parameters, and Antitumor Activity of Fe(III) Curcumin Complex.

ABSTRACT: Curcumin-Fe(III) complex was prepared from Fe(NO3)3 · 9H2O precursor and curcumin by refluxing a slightly basic methanolic solution of their mixture with the objective of investigating its cytotoxicity. The enol form of curcumin ligand was established by FTIR, UV/Vis, (1)H NMR, and (13)C NMR spectroscopy. The as-prepared product was characterized by elemental analysis, FTIR, UV, and Mössbauer spectroscopic techniques. An octahedral high-spin Fe(III) complex was obtained, ? , 0.37?mms(-1); Q.S., 0.79?mms(-1); no magnetic relaxation was observed at liquid N2 temperature, neither reduction of Fe(III). The tested cytotoxicity of the as-prepared complex on four cancer cell lines indicated inhibition of the curcumin activity upon complexing with iron.

SUBMITTER: Khalil MI 

PROVIDER: S-EPMC3623458 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature