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Oestrogen receptor polymorphisms and late-life depression.


ABSTRACT: Evidence suggests a role for oestrogen in depression but the involvement of oestrogen receptor polymorphisms remains unknown.To determine the association between oestrogen receptor polymorphisms and late-life depression and the modifying effect of hormone treatment.Depression was assessed using the Mini-International Neuropsychiatric Interview, according to DSM-IV criteria and the Centre for Epidemiologic Studies - Depression Scale. The association between oestrogen receptor ? and ? (ER-? and ER-?) polymorphisms with severe depression was examined in 6017 community-dwelling elderly people using multivariate logistic regression.In women, the ER-? rs2234693 and rs9340799 polymorphisms were significantly associated with the risk of late-life depression. The A allele of ER-? rs1256049 increased the risk of depression, but only for non-current users of hormone treatment. In men, only the ER-? rs4986938 polymorphism showed a weak association with depression risk.Oestrogen receptor polymorphisms are associated with severe late-life depression risk in women only.

SUBMITTER: Ryan J 

PROVIDER: S-EPMC3623726 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Oestrogen receptor polymorphisms and late-life depression.

Ryan Joanne J   Scali Jacqueline J   Carrière Isabelle I   Peres Karine K   Rouaud Olivier O   Scarabin Pierre-Yves PY   Ritchie Karen K   Ancelin Marie-Laure ML  

The British journal of psychiatry : the journal of mental science 20110801 2


<h4>Background</h4>Evidence suggests a role for oestrogen in depression but the involvement of oestrogen receptor polymorphisms remains unknown.<h4>Aims</h4>To determine the association between oestrogen receptor polymorphisms and late-life depression and the modifying effect of hormone treatment.<h4>Method</h4>Depression was assessed using the Mini-International Neuropsychiatric Interview, according to DSM-IV criteria and the Centre for Epidemiologic Studies - Depression Scale. The association  ...[more]

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