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Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells.

ABSTRACT: Metastatic establishment and growth of Lewis lung carcinoma is promoted by single-walled carbon nanotubes (SWCNT) in C57BL6/J mice. The effect is mediated by increased local and systemic accumulation of myeloid-derived suppressor cells (MDSC), as their depletion abrogated pro-tumor activity in vivo. These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment.

SUBMITTER: Shvedova AA

PROVIDER: S-EPMC3624038 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells.

Shvedova Anna A AA Tkach Alexey V AV Kisin Elena R ER Khaliullin Timur T Stanley Shyla S Gutkin Dmitriy W DW Star Alexander A Chen Yanan Y Shurin Galina V GV Kagan Valerian E VE Shurin Michael R MR

Small (Weinheim an der Bergstrasse, Germany) 20120920 9-10

Metastatic establishment and growth of Lewis lung carcinoma is promoted by single-walled carbon nanotubes (SWCNT) in C57BL6/J mice. The effect is mediated by increased local and systemic accumulation of myeloid-derived suppressor cells (MDSC), as their depletion abrogated pro-tumor activity in vivo. These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenv ...[more]

PMID: 22996965

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