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Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice.

ABSTRACT: Imaging strategies that detect early stage esophageal squamous cell carcinoma (ESCC) could improve clinical outcomes, when combined with endoscopic approaches. Periostin is an integrin-binding protein that is important in the tumor microenvironment. We created a fluorescent-labeled antibody that recognizes periostin and binds specifically to ESCC xenograft tumors in mice. In L2-cre;p120ctnLoxP/LoxP mice, which develop squamous cell cancers that resemble human ESCC, we visualized the probe in preneoplastic and neoplastic esophageal lesions using near-infrared fluorescent imaging with upper-gastrointestinal endoscopy. Periostin might be a biomarker of the esophageal tumor microenvironment that can be used to detect preneoplastic lesions.

SUBMITTER: Wong GS

PROVIDER: S-EPMC3624041 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice.

Wong Gabrielle S GS Habibollahi Peiman P Heidari Pedram P Lee Ju-Seog JS Klein-Szanto Andres J AJ Waldron Todd J TJ Gimotty Phyllis P Nakagawa Hiroshi H Taylor Philip R PR Wang Timothy C TC Mahmood Umar U Rustgi Anil K AK

Gastroenterology 20121022 2

Imaging strategies that detect early stage esophageal squamous cell carcinoma (ESCC) could improve clinical outcomes, when combined with endoscopic approaches. Periostin is an integrin-binding protein that is important in the tumor microenvironment. We created a fluorescent-labeled antibody that recognizes periostin and binds specifically to ESCC xenograft tumors in mice. In L2-cre;p120ctnLoxP/LoxP mice, which develop squamous cell cancers that resemble human ESCC, we visualized the probe in pre ...[more]

PMID: 23085486

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