Ontology highlight
ABSTRACT:
SUBMITTER: Wong GS
PROVIDER: S-EPMC3624041 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Gastroenterology 20121022 2
Imaging strategies that detect early stage esophageal squamous cell carcinoma (ESCC) could improve clinical outcomes, when combined with endoscopic approaches. Periostin is an integrin-binding protein that is important in the tumor microenvironment. We created a fluorescent-labeled antibody that recognizes periostin and binds specifically to ESCC xenograft tumors in mice. In L2-cre;p120ctnLoxP/LoxP mice, which develop squamous cell cancers that resemble human ESCC, we visualized the probe in pre ...[more]