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Anti-angiogenic activity of rPAI-1(23) and vasa vasorum regression.


ABSTRACT: The vasa vasorum are unique networks of vessels that become angiogenic in response to changes in the vessel wall. Structural studies, using various imaging modalities, show that the vasa vasorum form a plexus of microvessels during the atherosclerotic disease process. The events that stimulate vasa vasorum neovascularization remain unclear. Anti-angiogenic molecules have been shown to inhibit/regress the neovascularization; they provide significant insight into vasa vasorum function, structure, and specific requirements for growth and stability. This review discusses evidence for and against potential stimulators of vasa vasorum neovascularization. Anti-angiogenic rPAI-123, a truncated isoform of plasminogen activator inhibitor-1 (PAI-1) stimulates a novel pathway for regulating plasmin activity. This mechanism contributes significantly to vasa vasorum regression/collapse and is discussed as a model of regression.

SUBMITTER: Mulligan-Kehoe MJ 

PROVIDER: S-EPMC3624061 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Anti-angiogenic activity of rPAI-1(23) and vasa vasorum regression.

Mulligan-Kehoe Mary Jo MJ  

Trends in cardiovascular medicine 20130111 4


The vasa vasorum are unique networks of vessels that become angiogenic in response to changes in the vessel wall. Structural studies, using various imaging modalities, show that the vasa vasorum form a plexus of microvessels during the atherosclerotic disease process. The events that stimulate vasa vasorum neovascularization remain unclear. Anti-angiogenic molecules have been shown to inhibit/regress the neovascularization; they provide significant insight into vasa vasorum function, structure,  ...[more]

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