Ontology highlight
ABSTRACT:
SUBMITTER: Stewart CR
PROVIDER: S-EPMC3624204 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Stewart Cameron R CR Marsh Glenn A GA Jenkins Kristie A KA Gantier Michael P MP Tizard Mark L ML Middleton Deborah D Lowenthal John W JW Haining Jessica J Izzard Leonard L Gough Tamara J TJ Deffrasnes Celine C Stambas John J Robinson Rachel R Heine Hans G HG Pallister Jackie A JA Foord Adam J AJ Bean Andrew G AG Wang Lin-Fa LF
Journal of virology 20130123 7
Hendra virus is a highly pathogenic zoonotic paramyxovirus in the genus Henipavirus. Thirty-nine outbreaks of Hendra virus have been reported since its initial identification in Queensland, Australia, resulting in seven human infections and four fatalities. Little is known about cellular host factors impacting Hendra virus replication. In this work, we demonstrate that Hendra virus makes use of a microRNA (miRNA) designated miR-146a, an NF-κB-responsive miRNA upregulated by several innate immune ...[more]