Evolution of equine influenza virus in vaccinated horses.
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ABSTRACT:
SUBMITTER: Murcia PR
PROVIDER: S-EPMC3624384 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Evolution of equine influenza virus in vaccinated horses.
Murcia Pablo R PR Baillie Gregory J GJ Stack J Conrad JC Jervis Carley C Elton Debra D Mumford Jennifer A JA Daly Janet J Kellam Paul P Grenfell Bryan T BT Holmes Edward C EC Wood James L N JL
Journal of virology 20130206 8
Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naïve horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigeni ...[more]
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