Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk.

ABSTRACT:

Background

Emerging evidence suggests that single nucleotide polymorphisms (SNPs) in microRNA-coding genes may participate in the pathogenesis of lung cancer by altering the expression of tumor-related microRNAs. Several studies were investigated in recent years to evaluate the association between hsa-miR-196a2 rs11614913 polymorphism and increased/decreased lung cancer risk. In the present study, we performed a meta-analysis to systematically summarize the possible association.

Methodology/principal findings

We performed a meta-analysis of 4 case-control studies that included 2219 lung-cancer cases and 2232 cancer-free controls. We evaluated the strength of the association using odds ratios (ORs) with 95% confidence intervals (CIs). In the overall analysis, it was found that the rs11614913 polymorphism significantly elevated the risk of lung cancer (CC versus (vs.) TT OR?=?1.26, 95% CI 1.07-1.49, P?=?0.007; CC/CT vs. TT: OR?=?1.13, 95% CI 0.98-1.29, P?=?0.007; C vs. T: OR?=?1.12, 95% CI 1.03-1.22, P?=?0.008). In the subgroup analysis by ethnicity, statistically significantly increased cancer risk was found among Asians (CC vs. TT: OR?=?1.30, 95% CI 1.10-1.54, P?=?0.003; CT vs. TT: OR?=?1.16, 95% CI 1.01-1.34, P?=?0.039; CC vs. CT/TT: OR?=?1.21, 95% CI 1.04-1.41, P?=?0.012; C vs. T: OR?=?1.14, 95% CI 1.05-1.25, P?=?0.002). For Europeans, a significant association with lung cancer risk was found in recessive model (CC vs. CT/TT: OR?=?0.63, 95% CI 0.40-0.98, P?=?0.040). No publication bias was found in this study.

Conclusions/significance

Our meta-analysis suggests that the rs11614913 polymorphism is significant associated with the increased risk of lung cancer, especially in Asians. Besides, the C allele of rs11614913 polymorphism may contribute to increased lung cancer risk.

SUBMITTER: Yuan Z 

PROVIDER: S-EPMC3625214 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature