Ontology highlight
ABSTRACT:
SUBMITTER: Sueoka E
PROVIDER: S-EPMC3625215 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Sueoka Eisaburo E Sueoka-Aragane Naoko N Sato Akemi A Ide Masaru M Nakamura Hideaki H Sotomaru Yusuke Y Taya Choji C Yonekawa Hiromichi H Kitagawa Tomoyuki T Kubota Yasushi Y Kimura Shinya S Nakachi Kei K Tanimoto Keiji K
PloS one 20130412 4
Hypoxia-inducible factor-1alpha (HIF-1 alpha) plays an essential role in the regulation of various genes associated with low oxygen consumption. Elevated expression of HIF-1alpha has been reported to be associated with tumor progression, invasion and metastasis in many cancers. To investigate the role of HIF-1alpha in tumor development and metastasis, we established transgenic mice constitutively expressing HIF1A gene under regulation of the cytomegalovirus gene promoter. Although HIF-1alpha pro ...[more]