Ontology highlight
ABSTRACT:
SUBMITTER: Hofmann JP
PROVIDER: S-EPMC3625284 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Hofmann Julia P JP Denner Philip P Nussbaum-Krammer Carmen C Kuhn Peer-Hendrik PH Suhre Michael H MH Scheibel Thomas T Lichtenthaler Stefan F SF Schätzl Hermann M HM Bano Daniele D Vorberg Ina M IM
Proceedings of the National Academy of Sciences of the United States of America 20130318 15
Prions are self-templating protein conformers that replicate by recruitment and conversion of homotypic proteins into growing protein aggregates. Originally identified as causative agents of transmissible spongiform encephalopathies, increasing evidence now suggests that prion-like phenomena are more common in nature than previously anticipated. In contrast to fungal prions that replicate in the cytoplasm, propagation of mammalian prions derived from the precursor protein PrP is confined to the ...[more]