Ontology highlight
ABSTRACT:
SUBMITTER: Matarese G
PROVIDER: S-EPMC3625304 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Matarese Giuseppe G Procaccini Claudio C Menale Ciro C Kim Jae Geun JG Kim Jung Dae JD Diano Sabrina S Diano Nadia N De Rosa Veronica V Dietrich Marcelo O MO Horvath Tamas L TL
Proceedings of the National Academy of Sciences of the United States of America 20130325 15
Whole-body energy metabolism is regulated by the hypothalamus and has an impact on diverse tissue functions. Here we show that selective knockdown of Sirtuin 1 Sirt1 in hypothalamic Agouti-related peptide-expressing neurons, which renders these cells less responsive to cues of low energy availability, significantly promotes CD4(+) T-cell activation by increasing production of T helper 1 and 17 proinflammatory cytokines via mediation of the sympathetic nervous system. These phenomena were associa ...[more]