CAMP/PKA signaling defects in tumors: genetics and tissue-specific pluripotential cell-derived lesions in human and mouse.
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ABSTRACT:
SUBMITTER: Stratakis CA
PROVIDER: S-EPMC3625474 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
cAMP/PKA signaling defects in tumors: genetics and tissue-specific pluripotential cell-derived lesions in human and mouse.
Molecular and cellular endocrinology 20130226 1-2
In the last few years, bench and clinical studies led to significant new insight into how cyclic adenosine monophosphate (cAMP) signaling, the molecular pathway that had been identified in the early 2000s as the one involved in most benign cortisol-producing adrenal hyperplasias, affects adrenocortical growth and development, as well as tumor formation. A major discovery was the identification of tissue-specific pluripotential cells (TSPCs) as the culprit behind tumor formation not only in the a ...[more]
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