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An enzymatic route to selenazolines.


ABSTRACT: Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.

SUBMITTER: Koehnke J 

PROVIDER: S-EPMC3625746 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines. ...[more]

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