Ontology highlight
ABSTRACT:
SUBMITTER: Koehnke J
PROVIDER: S-EPMC3625746 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Koehnke Jesko J Morawitz Falk F Bent Andrew F AF Houssen Wael E WE Shirran Sally L SL Fuszard Matthew A MA Smellie Iain A IA Botting Catherine H CH Smith Margaret C M MC Jaspars Marcel M Naismith James H JH
Chembiochem : a European journal of chemical biology 20130218 5
Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines. ...[more]