Ontology highlight
ABSTRACT:
SUBMITTER: Monfils MH
PROVIDER: S-EPMC3625935 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Monfils Marie-H MH Cowansage Kiriana K KK Klann Eric E LeDoux Joseph E JE
Science (New York, N.Y.) 20090402 5929
Dysregulation of the fear system is at the core of many psychiatric disorders. Much progress has been made in uncovering the neural basis of fear learning through studies in which associative emotional memories are formed by pairing an initially neutral stimulus (conditioned stimulus, CS; e.g., a tone) to an unconditioned stimulus (US; e.g., a shock). Despite recent advances, the question of how to persistently weaken aversive CS-US associations, or dampen traumatic memories in pathological case ...[more]