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Aptamer-crosslinked microbubbles: smart contrast agents for thrombin-activated ultrasound imaging.

ABSTRACT: Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles.

SUBMITTER: Nakatsuka MA 

PROVIDER: S-EPMC3626403 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Aptamer-crosslinked microbubbles: smart contrast agents for thrombin-activated ultrasound imaging.

Nakatsuka Matthew A MA   Mattrey Robert F RF   Esener Sadik C SC   Cha Jennifer N JN   Goodwin Andrew P AP  

Advanced materials (Deerfield Beach, Fla.) 20120903 45

Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles. ...[more]

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