Ontology highlight
ABSTRACT:
SUBMITTER: Montrose K
PROVIDER: S-EPMC3627194 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Montrose Kristopher K Yang Yi Y Sun Xueying X Wiles Siouxsie S Krissansen Geoffrey W GW
Scientific reports 20130101
Here we describe an entirely new class of cell-penetrating peptide (CPP) represented by the short peptide Xentry (LCLRPVG) derived from an N-terminal region of the X-protein of the hepatitis B virus. Xentry permeates adherent cells using syndecan-4 as a portal for entry, and is uniquely restricted from entering syndecan-deficient, non-adherent cells, such as resting blood cells. Intravenous injection of Xentry alone or conjugated to β-galactosidase led to its delivery to most tissues in mice, ex ...[more]