Ontology highlight
ABSTRACT:
SUBMITTER: Dyer MJ
PROVIDER: S-EPMC3627333 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Therapeutic advances in hematology 20120801 4
There are now many therapeutic CD20 monoclonal antibodies undergoing clinical trials for B-cell malignancy and autoimmune conditions; which is optimal for cancer therapy is not clear. The novel human IgG1 CD20 monoclonal antibody ofatumumab has shown significant activity in difficult to treat patients with chronic lymphocytic leukemia, namely those resistant or refractory to fludarabine and alemtuzumab and has now been licensed for this uncommon indication. This brief review summarizes the clini ...[more]