Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure.
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ABSTRACT:
SUBMITTER: Fan X
PROVIDER: S-EPMC3627357 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
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Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure.
Fan Xueping X Li Qinggang Q Pisarek-Horowitz Anna A Rasouly Hila Milo HM Wang Xiangling X Bonegio Ramon G RG Wang Hang H McLaughlin Margaret M Mangos Steve S Kalluri Raghu R Holzman Lawrence B LB Drummond Iain A IA Brown Dennis D Salant David J DJ Lu Weining W
Cell reports 20120712 1
Robo2 is the cell surface receptor for the repulsive guidance cue Slit and is involved in axon guidance and neuronal migration. Nephrin is a podocyte slit-diaphragm protein that functions in the kidney glomerular filtration barrier. Here, we report that Robo2 is expressed at the basal surface of mouse podocytes and colocalizes with nephrin. Biochemical studies indicate that Robo2 forms a complex with nephrin in the kidney through adaptor protein Nck. In contrast to the role of nephrin that promo ...[more]
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