Ontology highlight
ABSTRACT:
SUBMITTER: Bolt MJ
PROVIDER: S-EPMC3627592 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Bolt Michael J MJ Stossi Fabio F Newberg Justin Y JY Orjalo Arturo A Johansson Hans E HE Mancini Michael A MA
Nucleic acids research 20130226 7
Nuclear receptors (NRs) are central regulators of pathophysiological processes; however, how their responses intertwine is still not fully understood. The aim of this study was to determine whether and how steroid NRs can influence each other's activity under co-agonist treatment. We used a unique system consisting of a multicopy integration of an estrogen receptor responsive unit that allows direct visualization and quantification of estrogen receptor alpha (ERα) DNA binding, co-regulator recru ...[more]