Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC3627827 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Liu Zheng Z MacRitchie Neil N Pyne Susan S Pyne Nigel J NJ Bittman Robert R
Bioorganic & medicinal chemistry 20130307 9
Sphingosine kinase 1 (SK1) is over-expressed in many cancers where it provides a selective growth and survival advantage to these cells. SK1 is thus a target for anti-cancer agents that can promote apoptosis of cancer cells. In previous work, we synthesized a novel allosteric SK1 inhibitor, (S)-FTY720 vinylphosphonate. We now report a more expeditious route to this inhibitor which features B-alkyl Suzuki coupling as a key step and show that replacement of the amino group in (S)-FTY720 vinylphosp ...[more]