Ontology highlight
ABSTRACT:
SUBMITTER: Diekman CO
PROVIDER: S-EPMC3627876 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Diekman Casey O CO Fall Christopher P CP Lechleiter James D JD Terman David D
Biophysical journal 20130401 8
A mathematical model that integrates the dynamics of cell membrane potential, ion homeostasis, cell volume, mitochondrial ATP production, mitochondrial and endoplasmic reticulum Ca(2+) handling, IP3 production, and GTP-binding protein-coupled receptor signaling was developed. Simulations with this model support recent experimental data showing a protective effect of stimulating an astrocytic GTP-binding protein-coupled receptor (P2Y1Rs) following cerebral ischemic stroke. The model was analyzed ...[more]