Ontology highlight
ABSTRACT:
SUBMITTER: Pihlajoki M
PROVIDER: S-EPMC3628026 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Endocrinology 20130307 5
Transcription factor GATA6 is expressed in the fetal and adult adrenal cortex and has been implicated in steroidogenesis. To characterize the role of transcription factor GATA6 in adrenocortical development and function, we generated mice in which Gata6 was conditionally deleted using Cre-LoxP recombination with Sf1-cre. The adrenal glands of adult Gata6 conditional knockout (cKO) mice were small and had a thin cortex. Cytomegalic changes were evident in fetal and adult cKO adrenal glands, and c ...[more]