Ontology highlight
ABSTRACT:
SUBMITTER: Dou Z
PROVIDER: S-EPMC3628298 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Molecular cell 20130221 1
Autophagy is an evolutionarily conserved membrane trafficking process. Induction of autophagy in response to nutrient limitation or cellular stress occurs by similar mechanisms in organisms from yeast to mammals. Unlike yeast, metazoan cells rely more on growth factor signaling for a wide variety of cellular activities including nutrient uptake. How growth factor availability regulates autophagy is poorly understood. Here we show that, upon growth factor limitation, the p110β catalytic subunit o ...[more]