Ontology highlight
ABSTRACT:
SUBMITTER: Falzone TT
PROVIDER: S-EPMC3628567 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Falzone Tobias T TT Oakes Patrick W PW Sees Jennifer J Kovar David R DR Gardel Margaret L ML
Biophysical journal 20130401 8
Dynamic regulation of the actin cytoskeleton is required for diverse cellular processes. Proteins regulating the assembly kinetics of the cytoskeletal biopolymer F-actin are known to impact the architecture of actin cytoskeletal networks in vivo, but the underlying mechanisms are not well understood. Here, we demonstrate that changes to actin assembly kinetics with physiologically relevant proteins profilin and formin (mDia1 and Cdc12) have dramatic consequences on the architecture and gelation ...[more]