Ontology highlight
ABSTRACT:
SUBMITTER: Conley JM
PROVIDER: S-EPMC3628818 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Cellular and molecular neurobiology 20130317 4
Activator of G protein signaling 3 (AGS3) binds Gα(i) subunits in the GDP-bound state, implicating AGS3 as an important regulator of Gα(i)-linked receptor (e.g., D2 dopamine and μ-opioid) signaling. We examined the ability of AGS3 to modulate recombinant adenylyl cyclase (AC) type 1 and 2 signaling in HEK293 cells following both acute and persistent activation of the D(2L) dopamine receptor (D(2L)DR). AGS3 expression modestly enhanced the potency of acute quinpirole-induced D(2L)DR modulation of ...[more]