Ontology highlight
ABSTRACT:
SUBMITTER: Holmes LV
PROVIDER: S-EPMC3629053 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20130416 4
In this study we have used multiplex ligation-dependent probe amplification (MLPA) to measure the copy number of CFHR3 and CFHR1 in DNA samples from 238 individuals from the UK and 439 individuals from the HGDP-CEPH Human Genome Diversity Cell Line Panel. We have then calculated the allele frequency and frequency of homozygosity for the copy number polymorphism represented by the CFHR3/CFHR1 deletion. There was a highly significant difference between geographical locations in both the allele fre ...[more]