Ontology highlight
ABSTRACT:
SUBMITTER: Barlow JH
PROVIDER: S-EPMC3629730 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Barlow Jacqueline H JH Faryabi Robert B RB Callén Elsa E Wong Nancy N Malhowski Amy A Chen Hua Tang HT Gutierrez-Cruz Gustavo G Sun Hong-Wei HW McKinnon Peter P Wright George G Casellas Rafael R Robbiani Davide F DF Staudt Louis L Fernandez-Capetillo Oscar O Nussenzweig André A
Cell 20130124 3
DNA double-strand breaks (DSBs) in B lymphocytes arise stochastically during replication or as a result of targeted DNA damage by activation-induced cytidine deaminase (AID). Here we identify recurrent, early replicating, and AID-independent DNA lesions, termed early replication fragile sites (ERFSs), by genome-wide localization of DNA repair proteins in B cells subjected to replication stress. ERFSs colocalize with highly expressed gene clusters and are enriched for repetitive elements and CpG ...[more]