Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC3629740 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Zhou Yanli Y Wang Jing J Liu Lantao L Wang Rongrong R Lai Xinhe X Xu Maotian M
ACS chemical neuroscience 20130124 4
Heme binds to amyloid β-peptide (Aβ) in the brain of Alzheimer's disease (AD) patients, thus forming Aβ-heme complexes and leading the characteristic pathological features of AD. The interaction between heme and Aβ might have important biological relevance to AD etiology. In this work, the electrochemical performances of heme after incubation with Aβ1-42, Aβ fragments, and mutated Aβ were systematically investigated using cyclic voltammetry and differential pulse voltammetry. Our results indicat ...[more]