Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior.
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ABSTRACT:
SUBMITTER: Barker JM
PROVIDER: S-EPMC3629946 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior.
Barker Jacqueline M JM Torregrossa Mary M MM Taylor Jane R JR
Nature neuroscience 20120826 10
The factors underlying vulnerability to alcoholism are largely unknown. We identified in rodents an innate endophenotype predicting individual risk for alcohol-related behaviors that was associated with decreased expression of the neuroplasticity-related polysialylated neural cell adhesion molecule (PSA-NCAM). Depletion of PSA-NCAM in the ventromedial prefrontal cortex was sufficient to render mice unable to extinguish alcohol seeking, indicating a causal role of naturally occurring variation. T ...[more]
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