Ontology highlight
ABSTRACT:
SUBMITTER: Park GH
PROVIDER: S-EPMC3630380 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Park Geun-Hee GH Kim Kyoung-Yeon KY Cho Sung Won SW Cheong Jae Youn JY Yu Gyeong Im GI Shin Dong Hoon DH Kwack Kyu Bum KB
Genomics & informatics 20130331 1
CD8+ T cells are key factors mediating hepatitis B virus (HBV) clearance. However, these cells are killed through HBV-induced apoptosis during the antigen-presenting period in HBV-induced chronic liver disease (CLD) patients. Interferon-inducible protein 6 (IFI6) delays type I interferon-induced apoptosis in cells. We hypothesized that single nucleotide polymorphisms (SNPs) in the IFI6 could affect the chronicity of CLD. The present study included a discovery stage, in which 195 CLD patients, in ...[more]