Ontology highlight
ABSTRACT:
SUBMITTER: Hendriksen IC
PROVIDER: S-EPMC3630454 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Hendriksen I C E IC Mtove G G Kent A A Gesase S S Reyburn H H Lemnge M M MM Lindegardh N N Day N P J NP von Seidlein L L White N J NJ Dondorp A M AM Tarning J J
Clinical pharmacology and therapeutics 20130208 5
Parenteral artesunate (ARS) is the drug of choice for the treatment of severe malaria. Pharmacokinetics data on intramuscular ARS are limited with respect to the main treatment group that carries the highest mortality, namely, critically ill children with severe malaria. A population pharmacokinetic study of ARS and dihydroartemisinin (DHA) was conducted from sparse sampling in 70 Tanzanian children of ages 6 months to 11 years. All the children had been admitted with severe falciparum malaria a ...[more]